Journal article
Serotonin contracts the isolated rat pylorus via a 5-HT2-like receptor
American journal of physiology. Regulatory, integrative and comparative physiology, v 266(1), pp R284-R291
01 Jan 1994
PMID: 8304552
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Serotonin (5-HT) produced concentration-dependent contractions of the isolated rat pylorus in vitro. Serotonergic contractions were antagonized by the calcium L-channel blocker, diltiazem, but not by tetrodotoxin or atropine. Three drugs that block 5-HT2 receptors, ketanserin, xylamidine, and methysergide, unsurmountably inhibited contractions to 5-HT. In contrast, antagonists of 5-HT3, 5-HT1A/1B, beta-adrenergic, or alpha 1-adrenergic receptors did not alter the response to 5-HT. Devazepide, an antagonist of cholecystokinin (CCK) type-A receptors, blocked contraction produced by CCK-8 but not by 5-HT. Conversely, the 5-HT2 antagonists did not affect CCK-stimulated contraction. These results suggest that 5-HT contracts the pylorus by a 5-HT2-like receptor on muscle and that this response occurs independently of CCKergic receptor mechanisms. Furthermore, the parallel between the overall pharmacological profile for serotonergic contraction of the pylorus and that observed previously for the anorectic action of peripheral 5-HT makes the pylorus a logical candidate for peripheral serotonergic control of feeding.
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Details
- Title
- Serotonin contracts the isolated rat pylorus via a 5-HT2-like receptor
- Creators
- K Eberle-Wang - Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129B. T Braun - Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129K. J Simansky - Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, v 266(1), pp R284-R291
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1994NA59800080
- Scopus ID
- 2-s2.0-0027957306
- Other Identifier
- 991014878246304721
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- Web of Science research areas
- Physiology