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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Serotonin of mast cell origin contributes to hippocampal function
The European journal of neuroscience, v 36(3), pp 2347-2359
Aug 2012
PMID: 22632453
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the central nervous system, serotonin, an important neurotransmitter and trophic factor, is synthesized by both mast cells and neurons. Mast cells, like other immune cells, are born in the bone marrow and migrate to many tissues. We show that they are resident in the mouse brain throughout development and adulthood. Measurements based on capillary electrophoresis with native fluorescence detection indicate that a significant contribution of serotonin to the hippocampal milieu is associated with mast cell activation. Compared with their littermates, mast cell-deficient C57BL/6 KitW-sh/W-sh mice have profound deficits in hippocampus-dependent spatial learning and memory and in hippocampal neurogenesis. These deficits are associated with a reduction in cell proliferation and in immature neurons in the dentate gyrus, but not in the subventricular zone a neurogenic niche lacking mast cells. Chronic treatment with fluoxetine, a selective serotonin reuptake inhibitor, reverses the deficit in hippocampal neurogenesis in mast cell-deficient mice. In summary, the present study demonstrates that mast cells are a source of serotonin, that mast cell-deficient C57BL/6 KitW-sh/W-sh mice have disrupted hippocampus-dependent behavior and neurogenesis, and that elevating serotonin in these mice, by treatment with fluoxetine, reverses these deficits. We conclude that mast cells contribute to behavioral and physiological functions of the hippocampus and note that they play a physiological role in neuroimmune interactions, even in the absence of inflammatory responses.
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Details
- Title
- Serotonin of mast cell origin contributes to hippocampal function
- Creators
- Katherine M. Nautiyal - Columbia UniversityChristopher A. Dailey - University of Illinois Urbana-ChampaignJaquelyn L. Jahn - Barnard CollegeElizabeth Rodriquez - Columbia UniversityNguyen Hong Son - University of Illinois Urbana-ChampaignJonathan V. Sweedler - University of Illinois Urbana-ChampaignRae Silver - Columbia University Irving Medical Center
- Publication Details
- The European journal of neuroscience, v 36(3), pp 2347-2359
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- P30DA018310 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission IOS 05-54514; DBI 320988 / NSF; National Science Foundation (NSF) F31MH084384 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01DE018866 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000307167400010
- Scopus ID
- 2-s2.0-84864824179
- Other Identifier
- 991021448029104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences