Journal article
Serotonin pharmacodynamics in hypothalamic tissues from young and old female rats
Brain research, v 421(1), pp 291-296
1987
PMID: 3690275
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to determine the effects of aging on serotonin (5-HT) pharmacodynamics in rostral hypothalamic tissue of female rats. Monoamine oxidase (MAO) activity was greater in old (19 months old) than in young (3 months old) animals. This difference resulted from a higher V
max for hypothalamic MAO from old rats, whereas K
m's were comparable in both age groups. These enzymatic changes were accompanied by altered uptake and release of [
3H]5-HT. Although [
3H]5-HT uptake was not different at equilibrium between groups, the equilibrium state was achieved more slowly by hypothalamic tissue from old rats. Basal and potassium-stimulated efflux of [
3H]5-HT was significantly greater in old rats compared with young ones and these differences remained during multiple depolarizations. The findings of this study suggest that synaptic levels of hypothalamic 5-HT increase with age. Since pharmacological simulation of this condition in young rats produces physiologic dysfunction, the spontaneous changes that occur in hypothalamic 5-HT pharmacodynamics during aging have the potential to promote senescence.
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Details
- Title
- Serotonin pharmacodynamics in hypothalamic tissues from young and old female rats
- Creators
- H.A. Navarro - University of KentuckyV.J. Aloyo - Drexel UniversityM.E. Rush - University of KentuckyR.F. Walker - Drexel University
- Publication Details
- Brain research, v 421(1), pp 291-296
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987K275800031
- Scopus ID
- 2-s2.0-0023621994
- Other Identifier
- 991019184184604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Neurosciences