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Journal article
Serotonin syndrome caused by drug to drug interaction between escitalopram and dextromethorphan
BMJ case reports, v 2017, bcr-2017-221486
07 Aug 2017
PMID: 28784915
Abstract
A 63-year-old woman with a history of long-standing depression, maintained on escitalopram, presented with altered mental status. Patient had recently been prescribed dextromethorphan-promethazine cough syrup 2 weeks prior for an upper respiratory tract infection. On admission, she was lethargic and obtunded and found to have inducible myoclonus on examination. The rest of her physical exam was unremarkable. Pertinent lab and imaging findings showed QTc prolongation on ECG, negative electroencephalogram and CT head findings, essentially normal blood tests and a negative toxicology screen. The patient was admitted to the step down unit for close observation; both escitalopram and the cough syrup were suspended and was supportively managed. Overnight the patient's mental status improved and the serial EcGs showed resolution of the prolonged QTc. Patient was discharged home without further complication.
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14 citations in Scopus
Details
- Title
- Serotonin syndrome caused by drug to drug interaction between escitalopram and dextromethorphan
- Creators
- Prudence Dy - Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USAVictor Arcega - Department of Medicine, Monmouth Medical Center, Long Branch, New Jersey, USAWael Ghali - Monmouth Medical CenterWinifred Wolfe - College of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- Publication Details
- BMJ case reports, v 2017, bcr-2017-221486
- Publisher
- British Medical Journal (BMJ)
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Scopus ID
- 2-s2.0-85027264367
- Other Identifier
- 991019173460304721