Journal article
Serotonin transporter gene polymorphism and antidepressant response
Neuroreport, v 11(1)
17 Jan 2000
PMID: 10683861
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined allelic polymorphisms of the serotonin transporter (5-HTT) gene and antidepressant response to 6 weeksʼ treatment with the selective serotonin reuptake inhibitor (SSRI) drugs fluoxetine or paroxetine. We genotyped 120 patients and 252 normal controls, using polymerase chain reaction of genomic DNA with primers flanking the second intron and promoter regions of the 5-HTT gene. Diagnosis of depression was not associated with 5-HTT polymorphisms. Patients homozygous I/I in intron2 or homozygous s/s in the promoter region showed better responses than all others (p < 0.0001, p = 0.0074, respectively). Lack of the I/I allele form in intron 2 most powerfully predicted non-response (83.3%). Response to SSRI drugs is related to allelic variation in the 5-HTT gene in depressed Korean patients.
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Details
- Title
- Serotonin transporter gene polymorphism and antidepressant response
- Creators
- Doh Kim - Samsung Medical CenterShinn-Won LimSoyoung LeeSung SohnSeonwoo KimChang HahnBernard CarrollSangil Lee - Psychology
- Publication Details
- Neuroreport, v 11(1)
- Publisher
- Lippincott Williams & Wilkins, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000084791600044
- Scopus ID
- 2-s2.0-0034677021
- Other Identifier
- 991019167973804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences