Journal article
Serum 25-Hydroxyvitamin D Concentration and Mortality from Heart Failure and Cardiovascular Disease, and Premature Mortality from All-Cause in United States Adults
The American journal of cardiology, v 110(6), pp 834-839
15 Sep 2012
PMID: 22658246
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We aimed to examine associations between serum 25-hydroxyvitamin D (25[OH]D) concentration and mortality from heart failure (HF) and cardiovascular disease (CVD) and premature death from all causes using data from the Third National Health and Nutrition Examination Survey, which included 13,131 participants (6,130 men, 7,001 women) ≥35 years old at baseline (1988 to 1994) and followed through December 2000. Premature death was defined all-cause death at <75 years of age. Results indicated that during an average 8-year follow-up, there were 3,266 deaths (24.9%) including 101 deaths from HF, 1,451 from CVD, and 1,066 premature all-cause deaths. Among HF deaths, 37% of decedents had serum 25(OH)D levels <20 ng/ml, whereas only 26% of those with non-HF deaths had such levels (p <0.001). Multivariate-adjusted Cox model indicated that subjects with serum 25(OH)D levels <20 ng/ml had 2.06 times higher risk (95% confidence interval 1.01 to 4.25) of HF death than those with serum 25(OH)D levels ≥30 ng/ml (p <0.001). In addition, hazard ratios (95% confidence intervals) for premature death from all causes were 1.40 (1.17 to 1.68) in subjects with serum 25(OH)D levels <20 ng/ml and 1.11 (0.93 to 1.33) in those with serum 25(OH)D levels of 20 to 29 ng/ml compared to those with serum 25(OH)D levels ≥30 ng/ml (p <0.001, test for trend). In conclusion, adults with inadequate serum 25(OH)D levels have significantly higher risk of death from HF and all CVDs and all-cause premature death.
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Details
- Title
- Serum 25-Hydroxyvitamin D Concentration and Mortality from Heart Failure and Cardiovascular Disease, and Premature Mortality from All-Cause in United States Adults
- Creators
- Longjian Liu - Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PennsylvaniaMing Chen - Department of Cardiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaShelley R Hankins - Division of Cardiology, Drexel University College of Medicine, Philadelphia, PennsylvaniaAna E Nùñez - Division of Internal Medicine, Drexel University College of Medicine, Philadelphia, PennsylvaniaRobert A Watson - Division of Cardiology, Abington Memorial Hospital, Abington, PennsylvaniaPerry J Weinstock - Division of Cardiovascular Disease, Cooper University Hospital, Camden, New JerseyCraig J Newschaffer - Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PennsylvaniaHoward J Eisen - Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania
- Publication Details
- The American journal of cardiology, v 110(6), pp 834-839
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Epidemiology and Biostatistics; Infectious Diseases (and HIV Medicine); A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000309250300012
- Scopus ID
- 2-s2.0-84865519560
- Other Identifier
- 991014878447704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems