Journal article
Serum 25-Hydroxyvitamin D and Physical Performance in Postmenopausal Women
Journal of women's health (Larchmont, N.Y. 2002), v 20(11), pp 163-1608
01 Nov 2011
PMID: 21923280
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:
Impairments in physical performance increase sharply with age. Low serum 25-hydroxyvitamin D (25-OHD) levels may be a modifiable risk factor for physical performance decline.
Methods:
Five hundred thirty-two participants in the Women's Health Initiative Clinical Trial (WHI CT) were among a 25% randomly selected subsample of women who participated in performance-based measures of physical performance at baseline, year 1, year 3, and year 6. A physical performance summary score was derived from three tests: timed walk, chair-stand, and grip strength. Levels of 25-OHD were measured at baseline. We used the generalized estimating equations (GEE) method to examine repeated measures of physical performance as a function of follow-up time since baseline according to 25-OHD concentration.
Results:
In 6 years of follow-up, participants with serum 25OHD ≥75 nmol/L had significantly higher scores for physical performance (β=2.64, 95% confidence interval [CI] 0.90-4.39) compared with the reference category (<35 nmol/L) after adjustment for age, chronic conditions, body mass index (BMI), race/ethnicity, time spent walking outside, trial arm, clinic latitude, and season of blood draw. However, the rate of decline in physical performance did not differ by level of 25OHD.
Conclusions:
Higher baseline serum 25-OHD was associated with better physical performance but did not reduce decline in physical performance over the 6-year period.
Metrics
Details
- Title
- Serum 25-Hydroxyvitamin D and Physical Performance in Postmenopausal Women
- Creators
- Yvonne L Michael - 1Drexel University School of Public Health, Philadelphia, PennsylvaniaEllen Smit - 2Oregon State University, Corvallis, OregonRebecca Seguin - 3Fred Hutchinson Cancer Research Center and the Group Health Research Institute, Seattle, WashingtonJ. David Curb - 4University of Hawaii John A. Burns School of Medicine, Honolulu, HawaiiLawrence S Phillips - 5Atlanta VA Medical Center, Decatur, Georgia, and Department of Medicine, Emory University, Atlanta, GeorgiaJoAnn E Manson - 6Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
- Publication Details
- Journal of women's health (Larchmont, N.Y. 2002), v 20(11), pp 163-1608
- Publisher
- Mary Ann Liebert, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000296924400003
- Scopus ID
- 2-s2.0-81155131861
- Other Identifier
- 991014878031904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Public, Environmental & Occupational Health
- Women's Studies