Journal article
Serum Fibroblast Growth Factor 21 Levels Are Inversely Associated with Growth Rates in Infancy
Hormone research in paediatrics, v 82(5), pp 324-331
01 Jan 2014
PMID: 25300595
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Fibroblast growth factor 21 (FGF21) is a metabolic and growth regulator. Aim: To investigate the role of FGF21 during growth in infancy. Methods: Blood samples for FGF21, leptin, insulin and glucose were collected from cord blood obtained from 95 preterm and term newborns (cross-sectional group), and at 6 and 12 months of life in 80 preterm and term infants (longitudinal group). Length and weight were measured at birth, 6 months, and 12 months. Results: From birth through 12 months of age, preterm infants' linear growth and weight gain were larger than those of term infants, irrespective of birth weight SDS. At birth and at 12 months, there was no difference in FGF21 levels between preterm and term infants; in contrast, at 6 months, serum FGF21 in term infants was significantly higher than that of preterm ones. In the 0-6-month period, in the whole longitudinal group, serum FGF21 was inversely correlated to the length change SDS, and such a significant inverse correlation persisted in the preterm-AGA group in the 6-12-month period. In addition, term infants who experienced length catch-up in the first 6 months of life exhibited lower serum FGF21 levels at 6 months, and those with length catch-up growth between 6 and 12 months had a greater decrease of serum FGF21 level in the same time period. Conclusions: Our results indicate that FGF21 in infancy is inversely correlated with linear growth rate, thus suggesting that FGF21 is a negative regulator of human growth. (C) 2014 S. Karger AG, Basel
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Details
- Title
- Serum Fibroblast Growth Factor 21 Levels Are Inversely Associated with Growth Rates in Infancy
- Creators
- Veronica Mericq - University of ChileFrancesco De Luca - Drexel Univ, Coll Med, St Christophers Hosp Children, Sect Endocrinol & Diabet, Philadelphia, PA 19104 USAMaria I. Hernandez - Drexel Univ, Coll Med, St Christophers Hosp Children, Sect Endocrinol & Diabet, Philadelphia, PA 19104 USAVeronica Pena - Univ Chile, San Borja Arriaran Hosp, Neonatol Unit, Santiago, ChileKatherine Rossel - Univ Chile, San Borja Arriaran Hosp, Neonatol Unit, Santiago, ChileMirna Garcia - Univ Chile, San Borja Arriaran Hosp, Neonatol Unit, Santiago, ChileAlejandra Avila - Univ Chile, Inst Maternal & Child Res, Fac Med, Santiago, ChileGabriel Cavada - Univ Chile, Dept Publ Hlth, Santiago, ChileGerman Iniguez - Univ Chile, Inst Maternal & Child Res, Fac Med, Santiago, ChileFrancesco DeLuca - Pediatrics
- Publication Details
- Hormone research in paediatrics, v 82(5), pp 324-331
- Publisher
- Karger
- Number of pages
- 8
- Grant note
- 1090028; 1110240 / Fondecyt; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT); CONICYT FONDECYT
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000345449800006
- Scopus ID
- 2-s2.0-84912109442
- Other Identifier
- 991019168903804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Pediatrics