Journal article
Serum Folate and Low-Density Lipoprotein Particle Size
Journal of atherosclerosis and thrombosis, v 17(12), pp 1218-1225
01 Jan 2010
PMID: 20808051
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aim: Nutritional parameters, such as B-vitamins, have not been studied for an association with low-density lipoprotein (LDL) particle size. The present study explored whether serum vitamin levels, including folate and vitamin B-12, could be associated with LDL particle size.
Methods: Using a randomly selected population of 255 hospital workers, we collected detailed lipid profiles, including triglyceride (TG), high-density lipoprotein (HDL) cholesterol, and LDL particle sizes. The peak particle size of LDL was measured by density gradient ultracentrifugation and a pore gradient lipoprotein system. Serum folate and vitamin B-12 levels were measured about 1 year later and analyzed. Carotid intima-media thickness (IMT) and hepatic steatosis were diagnosed ultrasonographically, and metabolic syndrome was diagnosed using ATP. criteria.
Results: LDL peak particle size was significantly correlated with carotid mean IMT (r =-0.16, p = 0.010). Serum folate levels were significantly and positively correlated with HDL cholesterol and negatively with TG, although the latter showed borderline significance. With increasing serum folate levels, the LDL peak particle size showed a gradual independent increase, even when adjusted for age, sex, hepatic steatosis, metabolic syndrome, and the TG/HDL cholesterol ratio.
Conclusion: Folate may act to enhance LDL particle size. Future clinical and research work should include a study of the safe application and manipulation of folate levels in order to control LDL particle size.
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Details
- Title
- Serum Folate and Low-Density Lipoprotein Particle Size
- Creators
- Dal-Sik Kim - Jeonbuk National UniversityYoung-Kon Kim - Samsung Medical CenterHyeong-Kyu Park - Soonchunhyang UniversityYoung I. Cho - Drexel UniversitySeul-Ki Jeong - Jeonbuk National University
- Publication Details
- Journal of atherosclerosis and thrombosis, v 17(12), pp 1218-1225
- Publisher
- Japan Atherosclerosis Soc
- Number of pages
- 8
- Grant note
- Chonbuk National University Hospital KSS-2006-002 / Korean Stroke Society Research Institute of Clinical Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000285648500003
- Scopus ID
- 2-s2.0-78650835754
- Other Identifier
- 991019167459804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Peripheral Vascular Disease