Journal article
Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer
Journal of oncology, v 2011(2011), pp 107-112
01 Jan 2011
PMID: 21977031
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background/Aims. Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients. Methods. ELISA was used to analyze MCP-1 serum levels in PDA (n = 62) and intraductal papillary mucinous neoplasms (IPMN) (n = 27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters. Results. Log MCP-1 values were significantly (P < 0.05) elevated in patients with BMI >= 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age. Conclusion. MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.
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Details
- Title
- Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer
- Creators
- Jennifer Sullivan - Thomas Jefferson UniversityQiaoke Gong - Thomas Jefferson UniversityTerry Hyslop - Thomas Jefferson UniversityHarish Lavu - Thomas Jefferson UniversityGalina Chipitsyna - Thomas Jefferson UniversityCharles J. Yeo - Thomas Jefferson UniversityHwyda A. Arafat - Thomas Jefferson University
- Publication Details
- Journal of oncology, v 2011(2011), pp 107-112
- Publisher
- Hindawi Publishing Group
- Number of pages
- 6
- Grant note
- 1R21 CA133753-02 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000215675000033
- Scopus ID
- 2-s2.0-84855257090
- Other Identifier
- 991022047281404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology