Journal article
Serum Parathyroid Hormone Predicts Mortality in Coronary Angiography Patients with Type 2 Diabetes
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v 105(11), dgaa512
Nov 2020
PMID: 32785694
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Elevated serum levels of parathyroid hormone (PTH), one of the main regulators of calcium homeostasis and vitamin D metabolism, have been proposed as predictors of mortality. The impact of type 2 diabetes mellitus (T2DM) on the putative association between PTH and mortality has not been investigated thus far. Aim: The aim of our study was to investigate the impact of T2DM on the power of PTH to predict mortality risk. Methods: Serum PTH levels were determined in 904 consecutive Caucasian patients referred to coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD), including 235 patients with T2DM. Prospectively, deaths were recorded over a mean follow-up period of 6.3 years. Results: PTH at baseline did not differ significantly between patients with and without T2DM (P= .307). Cox regression analysis revealed that the serum PTH level strongly predicted all-cause mortality in patients with T2DM (hazard ratio [HR] = 2.35 [1.37-4.03]; P= .002), whereas PTH did not predict all-cause mortality in patients without T2DM (HR = 1.04 [0.81432]; P= .766). The interaction term PTH x T2DM was significant (P= .006), indicating a significantly stronger impact of PTH on mortality risk in patients with T2DM than in individuals without diabetes. The impact of PTH on mortality risk in patients with T2DM remained significant after adjustment for glycated hemoglobin A1c, diabetes duration, classical cardiovascular risk factors, serum levels of vitamin D, and kidney function (HR = 2.10 [1.10-4.10]; P= .030). Conclusion: We conclude that PTH is a significantly stronger predictor of all-cause mortality in patients with T2DM than in those without T2DM.
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Details
- Title
- Serum Parathyroid Hormone Predicts Mortality in Coronary Angiography Patients with Type 2 Diabetes
- Publication Details
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v 105(11), dgaa512
- Publisher
- ENDOCRINE SOC; WASHINGTON
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000584540200008
- Scopus ID
- 2-s2.0-85090890188
- Other Identifier
- 991021860777804721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism