Journal article
Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study
Stroke (1970), v 52(12), pp 3953-3960
Dec 2021
PMID: 34412513
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite zinc's role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. To examine the association between serum zinc levels and incidence of ischemic stroke in a US population.
Using a case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke cohort, participants were randomly selected from the Reasons for Geographic and Racial Differences in Stroke cohort to generate a sub-cohort (n=2346). All incident ischemic stroke cases as of September 2012 (n=660) were included, with 62 incident cases overlapping in the sub-cohort. Serum zinc levels were measured at baseline. Barlow-weighted Cox's proportional hazards regression models were used to calculate multivariable-adjusted hazard ratios and the corresponding 95% CI of ischemic stroke by serum zinc levels.
The median zinc level for the sub-cohort was 121.19 µg/dL (interquartile range, 104.86-140.39 µg/dL). Serum zinc levels were inversely associated with incidence of ischemic stroke after adjustment for potential confounders (quartile 4 versus quartile 1: hazard ratio, 0.78 [95% CI, 0.61-0.98],
=0.03 for trend). When stratified by prespecified factors (sex, race, region), only sex showed a significant modification (
=0.03 for interaction). The inverse association was more pronounced among females (quartile 4 versus quartile 1: hazard ratio, 0.58 [95% CI, 0.41-0.84],
<0.01 for trend) than males (quartile 4 versus quartile 1: hazard ratio, 1.08 [95% CI, 0.78-1.51],
=0.92 for trend).
Serum zinc concentration was inversely associated with incidence of ischemic stroke, especially among women, indicating that low zinc levels may be a risk factor for ischemic stroke.
Metrics
Details
- Title
- Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study
- Creators
- Lindsey Mattern - Florida State UniversityCheng Chen - Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, NY (C.C., K.K.).Leslie A McClure - Drexel UniversityJohn Brockman - University of MissouriMary Cushman - University of VermontSuzanne Judd - University of Alabama at BirminghamKa Kahe - Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, NY (C.C., K.K.).
- Publication Details
- Stroke (1970), v 52(12), pp 3953-3960
- Grant note
- R01 ES021735 / NIEHS NIH HHS U01 NS041588 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000720456100043
- Scopus ID
- 2-s2.0-85121025354
- Other Identifier
- 991019168276904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Peripheral Vascular Disease