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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Serum creatinine elevation after switch to dolutegravir in a human immunodeficiency virus-positive kidney transplant recipient
Transplant infectious disease, v 18(4), pp 625-627
01 Aug 2016
PMID: 27159656
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dolutegravir is a preferred antiretroviral drug for human immunodeficiency virus (HIV)-infected patients following solid organ transplantation. It has potent antiretroviral activity and does not interact with calcineurin inhibitors. We describe a case of an HIV-infected kidney transplant patient, who was noted to have a rising serum creatinine following initiation of dolutegravir. At first, an acute rejection episode was suspected, but this finding was later attributed to inhibition of creatinine secretion by dolutegravir. We suggest that an awareness of this potential effect of dolutegravir is important for providers who take care of HIV-positive kidney transplant recipients, in order to prevent potentially unnecessary testing.
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Details
- Title
- Serum creatinine elevation after switch to dolutegravir in a human immunodeficiency virus-positive kidney transplant recipient
- Creators
- D. H. Lee - Drexel UniversityG. E. Malat - Drexel UniversityT. E. Bias - Drexel UniversityM. N. Harhay - Drexel UniversityK. Ranganna - Drexel UniversityA. M. Doyle - Drexel University
- Publication Details
- Transplant infectious disease, v 18(4), pp 625-627
- Publisher
- Wiley
- Number of pages
- 3
- Grant note
- K23DK105207 / National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K23DK105207 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Medicine (Graduate); College of Medicine; Design; Surgery
- Web of Science ID
- WOS:000385704700019
- Scopus ID
- 2-s2.0-84981156865
- Other Identifier
- 991019169419704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Transplantation