Journal article
Serum growth factors in asbestosis patients
Biomarkers, v 14(1), pp 61-66
Feb 2009
PMID: 19283526
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Various growth factors, including platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-β, have been implicated in the pathogenesis of asbestos-induced disease. PDGF and TGF-β levels were determined by enzyme-linked immunosorbent assays in the banked serum samples of a cohort of workers with asbestosis, and the relationships of the growth factor levels to the subsequent development of cancer and to the radiographic severity and progression of asbestosis in the cohort were examined. Serum levels of PDGF and TGF-β were found to be unrelated to the development of cancer, and serum levels of PDGF were found to be unrelated to the severity and progression of asbestosis. However, serum levels of TGF-β were found to be statistically significantly related to disease severity (p = 0.01), increasing approximately 2.4-fold from ILO radiographic category 0 to category 3, and they were marginally related to disease progression (p = 0.07), in multivariate analysis controlling for other contributory factors including cumulative asbestos exposure. This suggests that serum TGF-β may be a useful biomarker for asbestos-induced fibrotic disease.
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Details
- Title
- Serum growth factors in asbestosis patients
- Creators
- Yongliang Li - Columbia UniversityAntti Karjalainen - Finnish Institute of Occupational HealthHeikki Koskinen - Finnish Institute of Occupational HealthHarri Vainio - Finnish Institute of Occupational HealthEero Pukkala - Columbia UniversityKari Hemminki - German Cancer Research CenterPaul W. Brandt-Rauf - Columbia University
- Publication Details
- Biomarkers, v 14(1), pp 61-66
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000264138100009
- Scopus ID
- 2-s2.0-66149131097
- Other Identifier
- 991019323774804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Toxicology