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Serum leucine-rich α-2 glycoprotein 1 predicts 10-year mortality and vascular events in coronary angiography patients
Journal article   Peer reviewed

Serum leucine-rich α-2 glycoprotein 1 predicts 10-year mortality and vascular events in coronary angiography patients

Axel Muendlein, Andreas Leiherer, Eva Maria Brandtner, Kathrin Geiger, Christine Heinzle, Stella Gaenger, Laura Schnetzer, Andreas Festa, Christoph H. Saely and Heinz Drexel
Atherosclerosis, v 407, p120413
01 Aug 2025
DOI: https://doi.org/10.1016/j.atherosclerosis.2025.120413
PMID: 40577971
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Biomarker Coronary angiography LRG1 MACE Mortality
Leucine-rich α-2 glycoprotein 1 (LRG1) is a pro-inflammatory signaling molecule that is highly upregulated in various pathological conditions, including cardiovascular disease. We tested the hypothesis whether LRG1 levels are associated with incident all-cause mortality, vascular mortality, and major adverse cardiovascular events (MACE) in coronary angiography patients. A total of 695 patients referred for elective coronary angiography were included in the study. During a 10-year observational period, the incidence of all-cause mortality, vascular mortality, and MACE was recorded. Serum LRG1 levels were measured using an enzyme-linked immunosorbent assay. LRG1 showed highly significant correlations with increased age and C-reactive protein, as well as decreased estimated glomerular filtration rate, left ventricular ejection fraction, and triglycerides. LRG1 was higher in females compared to males and was elevated in patients with significant coronary artery disease (CAD) compared to those without CAD. Prospectively, higher LRG1 levels, analyzed in tertiles, significantly predicted incident all-cause mortality, vascular mortality, and MACE, independent of traditional risk factors. Adjusted hazard ratios [95 % confidence intervals] comparing the highest to the lowest tertile were 2.39 [1.58–3.62]; p < 0.001 for all-cause mortality, 2.05 [1.08–3.92]; p = 0.029 for vascular mortality, and 1.80 [1.19–2.75]; p = 0.006 for MACE. C-statistics and net reclassification improvement analyses demonstrated that LRG1 provided additional predictive value for all-cause mortality, beyond conventional risk factors. Serum LRG1 is a promising new predictor of all-cause mortality, vascular mortality, and MACE in coronary angiography patients. [Display omitted] •LRG1 predicts 10-year all-cause mortality, vascular mortality, and major adverse cardiovascular events.•The association between LRG1 and outcome risk is independent of traditional risk factors.•LRG1 enhances the predictive performance of a basic model that includes conventional risk factors for all-cause mortality.

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Collaboration types
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
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