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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Serum macrophage migration inhibitory factor in the prediction of preterm delivery
American journal of obstetrics and gynecology, v 199(1), pp 46.e1-46.e6
01 Jul 2008
PMCID: PMC2532504
PMID: 18241824
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Macrophage migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal macrophage migration inhibitory factor levels predicted subsequent preterm delivery.
A nested case-control study measuring serum macrophage migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of macrophage migration inhibitory factor with self-reported psychosocial variables.
Macrophage migration inhibitory factor was elevated in the preterm delivery cases (
P = .0004), and log macrophage migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-macrophage migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30).
High-serum macrophage migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.
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Details
- Title
- Serum macrophage migration inhibitory factor in the prediction of preterm delivery
- Creators
- Brad D. Pearce - Emory UniversitySicily E. Garvin - Emory UniversityJakob Grove - Aarhus UniversityElizabeth A. Bonney - University of VermontDonald J. Dudley - The University of Texas Health Science Center at San AntonioDiana E. Schendel - Centers for Disease Control and PreventionPoul Thorsen - Aarhus University
- Publication Details
- American journal of obstetrics and gynecology, v 199(1), pp 46.e1-46.e6
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000257205200015
- Scopus ID
- 2-s2.0-45649084679
- Other Identifier
- 991021229895504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology