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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study
European journal of nutrition, v 60(3), pp 1511-1520
01 Apr 2021
PMID: 32737612
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose To examine the prospective association between serum Mg level and the incidence of cognitive impairment.
Methods A random sub-cohort (n = 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75-0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.
Results After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96), P for linear trend = 0.08].
Conclusions Findings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.
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Details
- Title
- Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study
- Creators
- Cheng Chen - Columbia University Medical CenterPengcheng Xun - Indiana University BloomingtonFrederick Unverzagt - Indiana UniversityLeslie A. McClure - Drexel UniversityMarguerite Ryan Irvin - University of Alabama at BirminghamSuzanne Judd - University of Alabama at BirminghamMary Cushman - University of VermontKa He - Columbia Univ, Irving Med Ctr, Dept Obstet & Gynecol, 622 W 168th St,Suite 16-62, New York, NY 10032 USA
- Publication Details
- European journal of nutrition, v 60(3), pp 1511-1520
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- U01-NS-041588 / Department of Health and Human Services R01AG056111 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute of Neurological Disorders and Stroke, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) U01-DP-006302 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000554332200001
- Scopus ID
- 2-s2.0-85088785341
- Other Identifier
- 991019168294404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics