Journal article
Serum oncoproteins and growth factors in asbestosis and silicosis patients
International journal of cancer, v 50(6), pp 881-885
01 Apr 1992
PMID: 1313398
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Levels of 9 different oncoproteins and growth factors were assayed by immunoblotting with monoclonal antibodies in 91 serum samples collected between March 1983 and August 1987 from 46 pneumoconiosis patients (36 asbestosis, 10 silicosis) at high risk for the development of cancer. Follow‐up of these patients through June 1991 showed that 18 had developed cancer (11 lung, 2 pleural mesothelioma, 2 transitional‐cell carcinomas of the urinary bladder, 1 osteosarcoma, 1 non‐Hodgkin's lymphoma, 1 adenocarcinoma of the gallbladder). Increased serum levels of ras oncogene‐related protein (p21) were found in 7 of the 18 patients who developed cancer (5 lung, 2 pleural mesothelioma) versus 2 of the 28 patients without cancer, a statistically significant difference (p = 0.012). In addition, 6 of the 7 p21‐positive cancer cases had positive serum samples prior to clinical diagnosis of disease (average = 16.3 months, range = 3–26 months prior to diagnosis), suggesting that elevated serum p21 levels may be a useful marker for earlier detection in a significant percentage of respiratory malignancies. Finally, elevated serum levels of PDGF‐related protein were detected significantly more frequently in advanced pneumoconiosis cases (ILO radiographic classification of 2/1 or greater) than in less advanced cases (80% vs. 41.9%; p = 0.016), and there was a tendency for these PDGF‐positive patients to have progression of their disease (68.2% vs. 41.7%; p = 0.065), suggesting that elevated serum PDGF levels may be a marker for the development of severe and progressive pneumoconioses.
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Details
- Title
- Serum oncoproteins and growth factors in asbestosis and silicosis patients
- Creators
- Paul W. Brandt‐RaufSteven Smith - Columbia UniversityKari Hemminki - Cancer Risk Factors and PreventionHeikki Koskinen - Finnish Institute of Occupational HealthHarri Vainio - Finnish Institute of Occupational HealthHenry Niman - University of PittsburghJean Ford - Columbia University
- Publication Details
- International journal of cancer, v 50(6), pp 881-885
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 5
- Grant note
- Health of the Centers for Disease Control American Cancer Society National Institute for Occupational Safety (OH00076)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1992HM00600009
- Scopus ID
- 2-s2.0-0026523003
- Other Identifier
- 991019342552404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology