Journal article
Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection
The Journal of infectious diseases, v 210(10), pp 1549-1554
15 Nov 2014
PMID: 24864123
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits.
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Details
- Title
- Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection
- Creators
- Netanya G. Sandler - The University of Texas Medical Branch at GalvestonXinyan Zhang - National Institutes of HealthRonald J. Bosch - Johns Hopkins UniversityNicholas T. Funderburg - Harvard UniversityAndrew I. Choi - University of Colorado SystemJanet K. Robinson - Case Western Reserve UniversityDerek M. Fine - University of California SystemRobert W. Coombs - University of WashingtonJeffrey M. Jacobson - Rush UniversityAlan L. Landay - Drexel UniversityDaniel C. Douek - University of California, San FranciscoRandall Tressler - University of WashingtonSarah W. Read - Harvard UniversityCara C. Wilson - College Station Medical CenterSteven G. Deeks - The University of Texas Medical Branch at GalvestonMichael M. Lederman - Case Western Reserve UniversityRajesh T. Gandhi - Harvard UniversityAIDS Clinical Trials Grp A5296
- Publication Details
- The Journal of infectious diseases, v 210(10), pp 1549-1554
- Publisher
- Oxford Univ Press
- Number of pages
- 6
- Grant note
- R00HL108743 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) UM1AI068636 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) UL1TR000124 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) AI069471; 2UMIAI069511-08; UM1 AI069424; 5UO1 AI069502-07; A1-069513; 2UM1A I069432; UL1 TR001082; AI069477; UM1AI069495; UL1TR000124; 5-P30-AI-045008-15; UL1 RR024160; UM1-AI068636; P30-AI027757; AI-076174 / National Institutes of Health.; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01 AI-68636; AI-68634; 2UM1AI069452-08; AI069501; UM1-A1069424; UM1-AI069534-08; 2UM1AI069412-08 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1RR024160 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000344611200006
- Scopus ID
- 2-s2.0-84912144937
- Other Identifier
- 991019335243104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology