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Published, Version of Record (VoR) Open Access via Drexel Libraries Read and Publish Program 2026 Open CC BY V4.0
Journal article
Severe Postoperative Hemorrhage Following Dental Debridement in a Patient With PSPD
Special Care in Dentistry, v 46(4), e70233
Aug 2026
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Abstract
Background
Platelet Storage Pool Deficiency (PSPD) is a rare qualitative defect involving impaired granule secretion, often presenting with normal routine coagulation profiles. This case highlights the challenges of dental debridement in a young adult with special health care needs where functional platelet failure outweighs numerical counts.
Case Description
An 18-year-old required dental debridement under general anesthesia. Despite a multidisciplinary preoperative protocol involving desmopressin and antifibrinolytics, the patient encountered refractory postoperative hemorrhage. The bleeding exceeded the capacity of local hemostatic measures, necessitating an emergent blood transfusion for stabilization.
Practical Implications
This case underscores that pharmacological management of PSPD can be unpredictable. It reaffirms the necessity of the hospital-based “Medical Home” for special care populations, ensuring immediate access to blood products and interdisciplinary expertise. Practitioners must look beyond standard lab values when planning invasive procedures for patients with qualitative platelet dysfunction.
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Details
- Title
- Severe Postoperative Hemorrhage Following Dental Debridement in a Patient With PSPD
- Creators
- Dan Burch (Corresponding Author) - Drexel UniversityRichard F. Clark - Drexel UniversityMichael A Bianchi - Drexel University, College of Medicine
- Publication Details
- Special Care in Dentistry, v 46(4), e70233
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine; Surgery
- Other Identifier
- 991022200958004721