Journal article
Severity of obstructive sleep apnea in children with sickle cell disease
Journal of pediatric hematology/oncology, v 30(9), pp 659-665
01 Sep 2008
PMID: 18776757
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To characterize polysomnographic (PSG) findings of children with sickle cell disease (SCD) suspected of having sleep disordered breathing (SDB).
Methods: Families of 100 consecutively referred children with SCD completed the Children's Sleep Habit Questionnaire during a routine visit to identify concerns regarding sleep habits and sleep behavior. Of these, 48 children were identified as displaying behaviors suspicious of SDB. Nineteen agreed to an overnight PSG. The results from the PSGs of the SCD with obstructive sleep apnea syndrome (OSAS) group (SCD-OSAS; group 1) were compared with the results of 10 age, sex, and ethnicity-matched patients identified as OSAS with no medical comorbidities (uncomplicated OSAS; group 2).
Results: SDB was identified in 79% of the SCD group. As compared with the uncomplicated OSAS group, the SCD with OSAS group displayed nocturnal desaturation with lower nadir values, of longer duration, with a 4-fold increased risk for oxygen desaturation below 85%, higher percentage of total sleep time with end-tidal carbon dioxide (ET CO2) values > 50 mm Hg, with a 3.7-fold increased risk for spending more than 25% of total sleep time with ET CO2 more than 50 mm Hg and higher peak ET CO2 with a 7-fold increase for peak ET CO2 above 53 mm Hg.
Conclusions: Children with SCD suspicious of SDB may have not only a higher incidence of OSAS, but also more severe nocturnal desaturation and hypercapnia as compared with children with uncomplicated OSAS.
Metrics
Details
- Title
- Severity of obstructive sleep apnea in children with sickle cell disease
- Creators
- Joseph Kaleyias - Drexel UniversityNavid Mostofi - Drexel Univ, Coll Med, St Christophers Hosp Children, Sect Neurol & Sleep Med, Philadelphia, PA 19104 USAMitzie Grant - Drexel UniversityCamille Coleman - Drexel UniversityLori Luck - Drexel Univ, Coll Med, St Christophers Hosp Children, Marion Anderson Comprehens Sickle Cell Ctr, Philadelphia, PA 19104 USACarlton Dampier - Drexel Univ, Coll Med, St Christophers Hosp Children, Marion Anderson Comprehens Sickle Cell Ctr, Philadelphia, PA 19104 USASanjeev V. Kothare - Drexel Univ, Coll Med, St Christophers Hosp Children, Sect Neurol & Sleep Med, Philadelphia, PA 19104 USA
- Publication Details
- Journal of pediatric hematology/oncology, v 30(9), pp 659-665
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; Pediatrics
- Web of Science ID
- WOS:000259098300005
- Scopus ID
- 2-s2.0-66249136704
- Other Identifier
- 991019167965904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Oncology
- Pediatrics