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Journal article
Sevoflurane Postconditioning Ameliorates Oxygen-Glucose Deprivationu Reperfusion Injury in the Rat Hippocampus
CNS neuroscience & therapeutics, v 17(6), pp 605-611
01 Jan 2011
PMID: 20875045
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Sevoflurane is well known to exert a neuroprotective effect through anesthetic preconditioning. However, its effects on postconditioning, a neuroprotective phenomenon following an insult, have not been well studied. Aims: In this study, we examined the ability of sevoflurane to induce postconditioning in rat hippocampal slices, in vitro. Results: 2%, 4%, and 6% sevoflurane reduced neurophysiologic and morphologic neuronal injury following oxygenglucose deprivation (OGD) and reperfusion. The quantity of damaged neurons was significantly reduced on immunofluorescence staining; excitatory amino acids (Asp, Glu) increased and inhibitory amino acids (GABA) decreased significantly. The effect was concentration-dependent. Conclusion: Postconditioning with sevoflurane reduces neuronal damage after OGDreperfusion injury in the CA1 area of rat hippocampus, in vitro.
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Details
- Title
- Sevoflurane Postconditioning Ameliorates Oxygen-Glucose Deprivationu Reperfusion Injury in the Rat Hippocampus
- Creators
- Sheng Peng - Soochow UniversityPramood Kalikiri - Hahnemann University HospitalGeorge Mychaskiw - Hahnemann University HospitalDengxin Zhang - Suzhou Univ, Hosp 4, Dept Anesthesiol, Wuxi, Peoples R ChinaYan Zhang - Soochow UniversityGong-Jian Liu - Xuzhou Medical CollegeGuang-Lei Wang - Xuzhou Medical CollegeZhi-yun Shen - Soochow University
- Publication Details
- CNS neuroscience & therapeutics, v 17(6), pp 605-611
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- Baxter Healthcare, Inc.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Anesthesiology and Perioperative Medicine
- Web of Science ID
- WOS:000297316900005
- Scopus ID
- 2-s2.0-82355172757
- Other Identifier
- 991019167732104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy