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Sex difference in prevalence of depression after stroke
Journal article   Open access   Peer reviewed

Sex difference in prevalence of depression after stroke

Liming Dong, Brisa N Sánchez, Lesli E Skolarus, Eric Stulberg, Lewis B Morgenstern and Lynda D Lisabeth
Neurology, v 94(19), pp e1973-e1983
12 May 2020
DOI: https://doi.org/10.1212/WNL.0000000000009394
PMID: 32312890
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1212/wnl.0000000000009394View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open
url
https://doi.org/10.1212/WNL.0000000000009394View
Published, Version of Record (VoR) Open

Abstract

Aged Aged, 80 and over Depression - epidemiology Female Humans Male Middle Aged Prevalence Risk Factors Sex Characteristics Stroke - epidemiology Texas - epidemiology
This study investigated the sex difference in prevalence of depression at 90 days after first-ever stroke. Patients with first-ever stroke (n = 786) were identified from the population-based Brain Attack Surveillance in Corpus Christi project (2011-2016). Poststroke depressive symptoms were assessed by the 8-item Patient Health Questionnaire, and prestroke depression status (history and medication use) was self-reported. Logistic regression was used to examine the association between sex and depression after stroke, and effect modification by prestroke depression status, accounting for missing data. Women were more likely to have a history of and be on medication for depression at the time of stroke than men ( < 0.001). Prevalence of depression at 90 days was 28.2% for men (95% confidence interval [CI], 23.7%-32.8%) and 32.7% for women (95% CI, 27.8%-37.5%). The age-adjusted odds ratio (OR) of depression after stroke comparing women and men was 1.34 (95% CI, 0.97-1.85), and fully attenuated after adjustment for sociodemographic, stroke, and prestroke characteristics. Effect modification by prestroke depression status was present ( = 0.038). Among participants on medication for depression at the time of stroke, women were significantly less likely to have depression at 90 days compared with men (OR, 0.39; 95% CI, 0.16-0.96), whereas significant sex differences were not noted among those with and without a depression history. The sex difference in prevalence of depression at 90 days after first-ever stroke was not significant overall, but varied by prestroke depression status. Interventions to address and prevent poststroke depression are needed, particularly among those with prestroke depression but not undergoing treatment for depression at stroke onset.

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33 citations in Web of Science
31 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Clinical Neurology
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