Journal article
Sex differences in subclinical atherosclerosis by race/ethnicity in the multi-ethnic study of atherosclerosis
American journal of epidemiology, v 174(2), pp 165-172
15 Jul 2011
PMID: 21685409
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sex differences in cardiovascular disease mortality are more pronounced among non-Hispanic whites than other racial/ethnic groups, but it is unknown whether this variation is present in the earlier subclinical stages of disease. The authors examined racial/ethnic variation in sex differences in coronary artery calcification (CAC) and carotid intimal media thickness at baseline in 2000-2002 among participants (n = 6,726) in the Multi-Ethnic Study of Atherosclerosis using binomial and linear regression. Models adjusted for risk factors in several stages: age, traditional cardiovascular disease risk factors, behavioral risk factors, psychosocial factors, and adult socioeconomic position. Women had a lower prevalence of any CAC and smaller amounts of CAC when present than men in all racial/ethnic groups. Sex differences in the prevalence of CAC were more pronounced in non-Hispanic whites than in African Americans and Chinese Americans after adjustment for traditional cardiovascular disease risk factors, and further adjustment for behavioral factors, psychosocial factors, and socioeconomic position did not modify these results (for race/sex, P(interaction) = 0.047). Similar patterns were observed for amount of CAC among adults with CAC. Racial/ethnic variation in sex differences for carotid intimal media thickness was less pronounced. In conclusion, coronary artery calcification is differentially patterned by sex across racial/ethnic groups.
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Details
- Title
- Sex differences in subclinical atherosclerosis by race/ethnicity in the multi-ethnic study of atherosclerosis
- Creators
- Catherine Kim - University of MichiganAna V Diez-Roux - University of MichiganJennifer A Nettleton - The University of Texas Health Science Center at HoustonJoseph F Polak - Tufts UniversityWendy S Post - Johns Hopkins UniversityDavid S Siscovick - University of WashingtonKarol E Watson - University of California, Los AngelesAnjel M Vahratian - University of Michigan
- Publication Details
- American journal of epidemiology, v 174(2), pp 165-172
- Publisher
- Oxford University Press
- Grant note
- K23DK071552 / NIDDK NIH HHS R01 HL071759 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS N01-HC-95159 / NHLBI NIH HHS N01-HC-95160 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS K23 DK071552 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000292778600006
- Scopus ID
- 2-s2.0-79960548745
- Other Identifier
- 991020112047104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health