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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Sex-specific cell signalling: the corticotropin-releasing factor receptor model
Trends in pharmacological sciences (Regular ed.), v 34(8), pp 437-444
01 Aug 2013
PMID: 23849813
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Elucidating the biological basis for sex differences in diseases can reveal their pathophysiology and guide the development of individualized treatments. Here, we review evidence for the novel concept that receptor signaling can be sex biased such that the specific pathways engaged by ligand binding are determined by sex. As an example, this review focuses on the receptor for corticotropin-releasing factor (CRF), a stress-related peptide implicated in diverse psychiatric and medical disorders that are more prevalent in females. There is evidence for sex biases in CRF receptor coupling to G proteins and beta-arrestin that render females more sensitive to acute stress and less able to adapt to chronic stress. Taken with evidence for sex biased signaling in other receptor systems, the studies demonstrate the broad potential impact of this characteristic in determining sex differences in disease and therapeutic efficacy and underscore the importance of studying females in medical and pharmacological research.
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Details
- Title
- Sex-specific cell signalling: the corticotropin-releasing factor receptor model
- Creators
- Rita J. Valentino - Children's Hospital of PhiladelphiaElisabeth Van Bockstaele - Thomas Jefferson UniversityDebra Bangasser - Temple University
- Publication Details
- Trends in pharmacological sciences (Regular ed.), v 34(8), pp 437-444
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- K99MH092438 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) MH092438; 040008 / PHS; United States Department of Health & Human Services; United States Public Health Service
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000323802100006
- Scopus ID
- 2-s2.0-84881123234
- Other Identifier
- 991021903410404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy