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Journal article
Sexually Dimorphic Effects of a Western Diet on Brain Mitochondrial Bioenergetics and Neurocognitive Function
Nutrients, v 13(12), 4222
24 Nov 2021
PMID: 34959774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A Western diet (WD), high in sugars and saturated fats, impairs learning and memory function and contributes to weight gain. Mitochondria in the brain provide energy for neurocognitive function and may play a role in body weight regulation. We sought to determine whether a WD alters behavior and metabolic outcomes in male and female rodents through impacting hippocampal and hypothalamic mitochondrial bioenergetics. Results revealed a sexually dimorphic macronutrient preference, where males on the WD consumed a greater percentage of calories from fat/protein and females consumed a greater percentage of calories from a sugar-sweetened beverage. Both males and females on a WD gained body fat and showed impaired glucose tolerance when compared to same-sex controls. Males on a WD demonstrated impaired hippocampal functioning and an elevated tendency toward a high membrane potential in hippocampal mitochondria. Comprehensive bioenergetics analysis of WD effects in the hypothalamus revealed a tissue-specific adaption, where males on the WD oxidized more fat, and females oxidized more fat and carbohydrates at peak energy demand compared to same-sex controls. These results suggest that adult male rats show a susceptibility toward hippocampal dysfunction on a WD, and that hypothalamic mitochondrial bioenergetics are altered by WD in a sex-specific manner.
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Details
- Title
- Sexually Dimorphic Effects of a Western Diet on Brain Mitochondrial Bioenergetics and Neurocognitive Function
- Creators
- Magen N. Lord - University of GeorgiaJun-Won Heo - University of GeorgiaAlbino G. Schifino - University of GeorgiaJessica R. Hoffman - University of GeorgiaKristen N. Donohue - University of GeorgiaJarrod A. Call - University of GeorgiaEmily E. Noble - University of Georgia
- Publication Details
- Nutrients, v 13(12), 4222
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000736913500001
- Scopus ID
- 2-s2.0-85119695973
- Other Identifier
- 991022029669404721
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- Web of Science research areas
- Nutrition & Dietetics