Journal article
Sham feeding of sucrose increases the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus
Pharmacology, biochemistry and behavior, v 26(3), pp 585-591
01 Mar 1987
PMID: 3575375
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent pharmacological experiments suggested that central dopaminergic (DA) mechanisms are necessary for the normal eating response to sweet stimuli. To test this hypothesis, we measured the ratio of dihydroxyphenylacetic acid (DOPAC) to dopamine (DA) in forebrain DA terminal fields during the sham feeding of sucrose (1–40%) by rats after 17 hr of food deprivation. After 9 min of sham feeding 10% or 40% sucrose, DOPAC/DA increased in the hypothalamus, but not in other forebrain regions including the n. accumbens, amygdala, and pyriform cortex. This increase in hypothalamic DOPAC/DA did not occur after 9 min of sham feeding 1%, 1.25%, or 2.5% sucros. The increased DA metabolism required that sham feeding of 10% or 40% sucrose be maintained for longer than 3 min, because no increase of DOPAC/DA was observed in any forebrain region after 3 min of sham feeding. These results are strong evidence that hypothalamic DA mechanisms are activated by the sham feeding of sucrose solutions and they support the hypothesis that central DA mechanisms are necessary for the normal eating response to sweet stimuli.
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Details
- Title
- Sham feeding of sucrose increases the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus
- Creators
- G.P. Smith - NewYork–Presbyterian HospitalK.A. Bourbonais - NewYork–Presbyterian HospitalC. Jerome - NewYork–Presbyterian HospitalK.J. Simansky - Behavioral Pharma (United States)
- Publication Details
- Pharmacology, biochemistry and behavior, v 26(3), pp 585-591
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:A1987G608100019
- Scopus ID
- 2-s2.0-0023139795
- Other Identifier
- 991021842529904721
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InCites Highlights
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy