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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Shaping the synthesis of surfactant-stabilized oxygen microbubbles to accommodate encapsulated drug
Colloids and surfaces, B, Biointerfaces, v 208, 112049
Dec 2021
PMID: 34454362
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Developed oxygen-filled microbubbles for ultrasound-triggered oxygen/drug delivery.•Devised new fabrication method that more than doubled the microbubble yield.•Shell composition and acoustical properties unchanged.•Incorporated hydrophobic drug in microbubble shell.•Drug encapsulation efficiency doubled in new method.
We have developed oxygen filled microbubbles, SE61O2, for localized, ultrasound-triggered oxygen delivery to hypoxic tumors prior to radiation therapy. Microbubbles, created by sonication, have a shell composed of D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) and sorbitan monostearate. Preliminary studies in mice with breast tumor xenographs showed that increases in oxygen partial pressure levels lasted less than 3 min, which is insufficient for most clinical applications. Hence, we investigated the potential of incorporating a hydrophobic antiglycolytic drug, modeled with Nile red. A new fabrication method was developed by first creating drug-loaded TPGS micelles. The resulting microbubbles had similar shell compositions, physical size, morphology, and acoustic properties as the original method. However, microbubble yield was more than doubled, resulting in twice the encapsulation efficiency. For the TPGS micelle method these include similar shell compositions (94.4 ± 0.6 % Montane 60), physical size post freeze-drying and reconstitution (1.57 ± 0.42 μm), morphology (spherical), and acoustic properties (maximum enhancement 19.92 ± 0.55 dB). However, microbubble yield was more than doubled, resulting in twice the encapsulation efficiency (up to 10.49 %). We propose that a nonideal mixture is formed when the surfactants are combined by the standard method, resulting in the formation of mixed micelles that are more stable, making microbubble creation more difficult during the sonication step.
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Details
- Title
- Shaping the synthesis of surfactant-stabilized oxygen microbubbles to accommodate encapsulated drug
- Creators
- Purva B. Vaidya - Drexel UniversityBrian E. Oeffinger - Drexel UniversityRaj Patel - Drexel UniversityQuezia Lacerda - Thomas Jefferson UniversityJacob Powell - Drexel UniversityJohn R. Eisenbrey - Thomas Jefferson UniversityMargaret A. Wheatley - Drexel University
- Publication Details
- Colloids and surfaces, B, Biointerfaces, v 208, 112049
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Chemistry
- Web of Science ID
- WOS:000703590900001
- Scopus ID
- 2-s2.0-85113421493
- Other Identifier
- 991019168223604721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Chemistry, Physical
- Materials Science, Biomaterials