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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Shear-Thinning Supramolecular Hydrogels with Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo
Advanced functional materials, v 25(4), pp 636-644
28 Jan 2015
PMID: 26526097
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Clinical percutaneous delivery of synthetically engineered hydrogels remains limited due to challenges posed by crosslinking kineticstoo fast leads to delivery failure, too slow limits material retention. To overcome this challenge, supramolecular assembly is exploited to localize hydrogels at the injection site and introduce subsequent covalent crosslinking to control final material properties. Supramolecular gels are designed through the separate pendant modifications of hyaluronic acid (HA) by the guest-host pair cyclodextrin and adamantane, enabling shear-thinning injection and high target site retention (>98%). Secondary covalent crosslinking occurs via addition of thiols and Michael-acceptors (i.e., methacrylates, acrylates, vinyl sulfones) on HA and increases hydrogel moduli (E = 25.0 +/- 4.5 kPa) and stability (>3.5 fold in vivo at 28 d). Application of the dual-crosslinking hydrogel to a myocardial infarct model shows improved outcomes relative to untreated and supramolecular hydrogel alone controls, demonstrating its potential in a range of applications where the precise delivery of hydrogels with tunable properties is desired.
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Details
- Title
- Shear-Thinning Supramolecular Hydrogels with Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo
- Creators
- Christopher B. Rodell - University of PennsylvaniaJohn W. MacArthur - University of PennsylvaniaShauna M. Dorsey - University of PennsylvaniaRyan J. Wade - University of PennsylvaniaLeo L. Wang - University of PennsylvaniaY. Joseph Woo - Stanford UniversityJason A. Burdick - University of Pennsylvania
- Publication Details
- Advanced functional materials, v 25(4), pp 636-644
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- American Heart Association R01HL089315 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01 HL111090; R01 HL089315 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000348856500015
- Scopus ID
- 2-s2.0-85027954602
- Other Identifier
- 991019176646904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter