Journal article
Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction
Case reports in gastrointestinal medicine, v 2017(2017), pp 1-5
01 Jan 2017
PMID: 28326205
Abstract
Worldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases of Shigella infection are reported annually in the United States. Shigella bacteremia is uncommon and generally seen in children and immunocompromised adults. We present a case of a Shigella sonnei bacteremia with marked hepatic derangement in a 27-year-old previously healthy homosexual male with history of Roux-en-Y gastric bypass, who presented to the emergency room with a 4-day history of loose watery stool, abdominal cramps, nausea and vomiting, and yellow skin of 2-day duration. He reports similar diarrhea illness in two close contacts in preceding days. On examination, he was fully oriented but dehydrated, icteric, and febrile. Laboratory data revealed WBC of 2200/μL, elevated AST and ALT (201 IU/L, 73 IU/L resp.), normal alkaline phosphatase, elevated total and direct bilirubin of 8.2 mg/dL and 4.4 mg/dL, albumin of 3.2 g/dL, INR of 2.9, prothrombin time of 31.7, and platelet of 96,000/μL. Workup for infectious, autoimmune and medication-induced hepatitis, Wilson's disease, and hemochromatosis was negative. Abdominal ultrasound and computed tomography of the abdomen showed hepatic steatosis and right-sided colitis. Stool and blood cultures were positive for Shigella sonnei. He was treated with ciprofloxacin with improvement in liver function. Follow-up blood test 4 months later was within normal limits.
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Details
- Title
- Shigella sonnei Bacteremia Presenting with Profound Hepatic Dysfunction
- Creators
- Oluwaseun Shogbesan - Reading HospitalAndrew Rettew - Banner - University Medical Center TucsonBilal Shaikh - St. Francis Medical CenterAbdullateef Abdulkareem - Reading HospitalAnthony Donato - Reading Hospital
- Publication Details
- Case reports in gastrointestinal medicine, v 2017(2017), pp 1-5
- Publisher
- Hindawi Publishing Corporation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000394620000001
- Other Identifier
- 991022161838904721