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Journal article
Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study
Arthritis and rheumatism, v 59(5), pp 721-729
15 May 2008
PMID: 18438902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE).
Methods. The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded.
Results. There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.
Conclusion. In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.
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Details
- Title
- Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study
- Creators
- J. G. Hanly - Dalhousie UniversityM. B. Urowitz - University of TorontoL. Su - University of CambridgeJ. Sanchez-Guerrero - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránS. C. Bae - Hanyang UniversityC. Gordon - University of BirminghamD. J. Wallace - University of California, Los AngelesD. Isenberg - UCL AustraliaG. S. Alarcon - University of Alabama at BirminghamJ. T. Merrill - Oklahoma Medical Research FoundationA. Clarke - McGill UniversityS. Bernatsky - McGill UniversityM. A. Dooley - University of North Carolina at Chapel HillP. R. Fortin - University of TorontoD. Gladman - University of TorontoK. Steinsson - National University Hospital of IcelandM. Petri - Johns Hopkins UniversityI. N. Bruce - University of ManchesterS. Manzi - University of PittsburghM. Khamashta - King's College LondonA. Zoma - Hairmyres HospitalJ. Font - Queen Elizabeth II Health Sciences CentreR. Van Vollenhoven - Karolinska InstitutetC. Aranow - Columbia UniversityE. Ginzler - SUNY Downstate Health Sciences UniversityO. Nived - Lund UniversityG. Sturfelt - Lund UniversityR. Ramsey-Goldman - Northwestern UniversityK. Kalunian - University of California, San DiegoJ. Douglas - Dalhousie UniversityK. Qiufen Qi - Dalhousie UniversityK. Thompson - Dalhousie UniversityV. Farewell - University of CambridgeSystemic Lupus Int Collaborating C
- Publication Details
- Arthritis and rheumatism, v 59(5), pp 721-729
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- R01AR043727 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Wellcome Trust; European Commission M01RR000048 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 86526-2; 86526-1 / CIHR; Canadian Institutes of Health Research (CIHR) M01 RR000052; M01 RR000048; M01 RR 00048; M01 RR 00052 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) K24 AR 02318; P60 AR048095; R01 AR043727; P60 AR 48095; P60 AR048098; K24 AR002138; AR 43727; P60 AR 48098 / NIAMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) MC_U105261167 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission MC_U105261167 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000255848000017
- Scopus ID
- 2-s2.0-43549088352
- Other Identifier
- 991021934006104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology