Files and links (1)
Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort
EClinicalMedicine, v 11, pp 27-33
01 May 2019
PMID: 31312804
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment.
Methods: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled a national cohort of 30,239 white and black Americans from 2003 to 7, who are followed every 6 months. Baseline and annual global cognitive function testing used the Six-Item Screener (SIS), a validated instrument (scores range 0-6; <= 4 indicates cognitive impairment). Participants with baseline cognitive impairment and whites were excluded. Logistic regression was used to calculate the association of SCT with incident cognitive impairment, adjusted for risk factors. Linear mixed models assessed multivariable-adjusted change in test scores on a biennially administered 3-test battery measuring learning, memory, and semantic and phonemic fluency.
Findings: Among 7743 participants followed for a median of 7.1 years, 85 of 583 participants with SCT (14.6%) developed incident cognitive impairment compared to 902 of 7160 (12.6%) without SCT. In univariate analysis, the odds ratio (OR) of incident cognitive impairment was 1.18 (95% CI: 0.93, 1.51) for those with SCT vs. those without. Adjustment did not impact the OR. There was no difference in change on 3-test battery scores by SCT status (all p > 0.11).
Interpretation: In this prospective cohort study of black Americans, SCT was not associated with incident cognitive impairment or decline in test scores of learning, memory and executive function. (C) 2019 Published by Elsevier Ltd.
Metrics
Details
- Title
- Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort
- Creators
- Christina R. Cahill - University of VermontJustin M. Leach - University of Alabama at BirminghamLeslie A. McClure - Drexel UniversityMarguerite Ryan Irvin - University of Alabama at BirminghamNeil A. Zakai - University of VermontRakhi Naik - Johns Hopkins UniversityFrederick Unverzagt - Indiana UniversityVirginia G. Wadley - University of Alabama at BirminghamHyacinth Hyacinth - Children's Healthcare of AtlantaJennifer Manly - Columbia University Medical CenterSuzanne E. Judd - University of Alabama at BirminghamCheryl Winkler - Molecular Genetics Epidemiology Section, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States of America.Mary Cushman - University of Vermont
- Publication Details
- EClinicalMedicine, v 11, pp 27-33
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- U01NS041588 / National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) HHSN26120080001E / Intramural Research Program of the National Cancer Institute Center for Cancer Research, NIH American Society of Hematology HONORS Award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000646584800008
- Scopus ID
- 2-s2.0-85065965707
- Other Identifier
- 991019168321004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology