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Journal article
Sighting acute myocardial infarction through platelet gene expression
Scientific reports, v 9(1), pp 19574-8
20 Dec 2019
PMID: 31863085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Acute myocardial infarction is primarily due to coronary atherosclerotic plaque rupture and subsequent thrombus formation. Platelets play a key role in the genesis and progression of both atherosclerosis and thrombosis. Since platelets are anuclear cells that inherit their mRNA from megakaryocyte precursors and maintain it unchanged during their life span, gene expression profiling at the time of an acute myocardial infarction provides information concerning the platelet gene expression preceding the coronary event. In ST-segment elevation myocardial infarction (STEMI), a gene-by-gene analysis of the platelet gene expression identified five differentially expressed genes: FKBP5, S100P, SAMSN1, CLEC4E and S100A12. The logistic regression model used to combine the gene expression in a STEMI vs healthy donors score showed an AUC of 0.95. The same five differentially expressed genes were externally validated using platelet gene expression data from patients with coronary atherosclerosis but without thrombosis. Platelet gene expression profile highlights five genes able to identify STEMI patients and to discriminate them in the background of atherosclerosis. Consequently, early signals of an imminent acute myocardial infarction are likely to be found by platelet gene expression profiling before the infarction occurs.
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Details
- Title
- Sighting acute myocardial infarction through platelet gene expression
- Creators
- Giuliana Gobbi - University of ParmaCecilia Carubbi - University of ParmaGuidantonio Malagoli Tagliazucchi - Ospedale di ParmaElena Masselli - University of ParmaPrisco Mirandola - University of ParmaFilippo Pigazzani - Ospedale di ParmaAntonio Crocamo - Ospedale di ParmaMaria Francesca Notarangelo - Ospedale di ParmaSergio Suma - Ospedale di ParmaElvezia Paraboschi - Humanitas UniversityGiuseppe Maglietta - Ospedale di ParmaSrikanth Nagalla - Southwestern Medical CenterGiulia Pozzi - University of ParmaDaniela Galli - University of ParmaMauro Vaccarezza - Curtin UniversityPaolo Fortina - Kimmel Cancer CenterSankar Addya - Kimmel Cancer CenterAdam Ertel - Sidney Kimmel Cancer CenterPaul Bray - University of UtahStefano Duga - Humanitas UniversityCarlo Berzuini - University of ManchesterMarco Vitale - University of ParmaDiego Ardissino - Ospedale di Parma
- Publication Details
- Scientific reports, v 9(1), pp 19574-8
- Publisher
- Springer Nature
- Grant note
- R01 HL141424 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000508872700020
- Scopus ID
- 2-s2.0-85076919837
- Other Identifier
- 991019176647904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems