Journal article
Signaling by olfactory receptor neurons near threshold
Proceedings of the National Academy of Sciences - PNAS, v 107(43), pp 18682-18687
26 Oct 2010
PMID: 20930117
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An important contributing factor for the high sensitivity of sensory systems is the exquisite sensitivity of the sensory receptor cells. We report here the signaling threshold of the olfactory receptor neuron (ORN). We first obtained a best estimate of the size of the physiological electrical response successfully triggered by a single odorant-binding event on a frog ORN, which was ∼0.034 pA and had an associated transduction domain spanning only a tiny fraction of the length of an ORN cilium. We also estimated the receptor-current threshold for an ORN to fire action potentials in response to an odorant pulse, which was ∼1.2 pA. Thus, it takes about 35 odorant-binding events successfully triggering transduction during a brief odorant pulse in order for an ORN to signal to the brain.
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Details
- Title
- Signaling by olfactory receptor neurons near threshold
- Creators
- Vikas Bhandawat - Solomon H. Snyder Department of Neuroscience and Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. bhandawat@gmail.comJohannes ReisertKing-Wai Yau
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 107(43), pp 18682-18687
- Publisher
- PNAS; United States
- Grant note
- DC06904 / NIDCD NIH HHS R01 DC006904 / NIDCD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000283677400082
- Scopus ID
- 2-s2.0-78649900248
- Other Identifier
- 991014877810104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences