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Journal article
Signalling through the IL-2 receptor gamma(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria
Parasite immunology, v 33(9), pp 512-516
01 Sep 2011
PMID: 21585397
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of alpha, beta and gamma chains is required for the suppression of Plasmodium chabaudi adami parasitemia. Blood-stage infections in IL-2R gamma(-/y)(c) mice failed to cure with parasitemia remaining elevated for >50 days indicating the IL-2R gamma(c) through which all members of the gamma(c) family of cytokines signal has an essential role in protective immunity against blood-stage malarial parasites. In contrast, the curing of parasitemia in IL-2/15R beta(-/-) mice, deficient in both IL-2 and IL-15 signalling was significantly delayed but did occur, indicating that neither cytokine plays an essential role in parasite clearance. Moreover, the observation that the time course of parasitemia in IL-15(-/-) mice was nearly identical to that seen in controls suggests that the parasitemia-suppressing role of stimulating through the IL-2/15R beta chain is owing to IL-2 signalling and not a redundant function of IL-15.
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Details
- Title
- Signalling through the IL-2 receptor gamma(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria
- Creators
- W. P. Weidanz - University of Wisconsin–MadisonG. LaFleur - University of Wisconsin–MadisonA. Kita-Yarbro - University of Wisconsin–MadisonK. Nelson - University of Wisconsin–MadisonJ. M. Burns - Drexel University
- Publication Details
- Parasite immunology, v 33(9), pp 512-516
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- R01AI049585 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) AI12710; AI49585 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Health Management and Policy
- Web of Science ID
- WOS:000293794600005
- Scopus ID
- 2-s2.0-80051604348
- Other Identifier
- 991019168327604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Parasitology