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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus)
Molecular ecology, v 26(22), pp 6336-6350
Nov 2017
PMID: 28980357
Abstract
Urbanization significantly alters natural ecosystems and has accelerated globally. Urban wildlife populations are often highly fragmented by human infrastructure, and isolated populations may adapt in response to local urban pressures. However, relatively few studies have identified genomic signatures of adaptation in urban animals. We used a landscape genomic approach to examine signatures of selection in urban populations of white-footed mice (Peromyscus leucopus) in New York City. We analysed 154,770 SNPs identified from transcriptome data from 48 P. leucopus individuals from three urban and three rural populations and used outlier tests to identify evidence of urban adaptation. We accounted for demography by simulating a neutral SNP data set under an inferred demographic history as a null model for outlier analysis. We also tested whether candidate genes were associated with environmental variables related to urbanization. In total, we detected 381 outlier loci and after stringent filtering, identified and annotated 19 candidate loci. Many of the candidate genes were involved in metabolic processes and have well-established roles in metabolizing lipids and carbohydrates. Our results indicate that white-footed mice in New York City are adapting at the biomolecular level to local selective pressures in urban habitats. Annotation of outlier loci suggests selection is acting on metabolic pathways in urban populations, likely related to novel diets in cities that differ from diets in less disturbed areas.
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Details
- Title
- Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus)
- Creators
- Stephen E Harris - The Graduate Center, CUNYJason Munshi-South - Fordham University
- Publication Details
- Molecular ecology, v 26(22), pp 6336-6350
- Publisher
- Wiley
- Grant note
- R15 GM099055 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biodiversity, Earth, and Environmental Science (BEES)
- Web of Science ID
- WOS:000417241800011
- Scopus ID
- 2-s2.0-85032955753
- Other Identifier
- 991021903955104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Ecology
- Evolutionary Biology