Journal article
Significance of isomerization in hydroxocobalamin
Biochemical and biophysical research communications, v 125(2), pp 698-703
1984
PMID: 6517920
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hydroxocobalamin is present in fairly large proportions both in foods and in the human body and apparently plays an important biological role. Since cyanocobalamin seems to play hardly any significant biochemical role in healthy humans, several physicians prefer to administer hydroxocobalamin to vitamin B
12 deficient patients. We find that hydroxocobalamin in solution isomerizes very readily at room and lower temperatures. Our observations raise the question whether “Mother Nature” has gone awry in using an easily convertible substance like hydroxocobalamin or that the new isomeric forms play some significant role. These observations may also have a bearing on the reported occurrence of unidentified corrinoids in animal tissues, human red cells, liver and brain.
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Details
- Title
- Significance of isomerization in hydroxocobalamin
- Creators
- Rakesh K. Kohli - Drexel UniversityAmar Nath - Drexel University
- Publication Details
- Biochemical and biophysical research communications, v 125(2), pp 698-703
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1984TW34700036
- Scopus ID
- 2-s2.0-0021673049
- Other Identifier
- 991019173655604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics