Journal article
Significant correlation of species longevity with DNA double strand break recognition but not with telomere length
Mechanisms of ageing and development, v 130(11), pp 784-792
2009
PMID: 19896964
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The identification of the cellular mechanisms responsible for the wide differences in species lifespan remains one of the major unsolved problems of the biology of aging. We measured the capacity of nuclear protein to recognize DNA double strand breaks (DSBs) and telomere length of skin fibroblasts derived from mammalian species that exhibit wide differences in longevity. Our results indicate DNA DSB recognition increases exponentially with longevity. Further, an analysis of the level of Ku80 protein in human, cow, and mouse suggests that Ku levels vary dramatically between species and these levels are strongly correlated with longevity. In contrast mean telomere length appears to decrease with increasing longevity of the species, although not significantly. These findings suggest that an enhanced ability to bind to DNA ends may be important for longevity. A number of possible roles for increased levels of Ku and DNA-PKcs are discussed.
Metrics
Details
- Title
- Significant correlation of species longevity with DNA double strand break recognition but not with telomere length
- Creators
- Antonello Lorenzini - Drexel UniversityF. Brad Johnson - University of PennsylvaniaAnthony Oliver - Lankenau Institute for Medical ResearchMaria Tresini - Lankenau Institute for Medical ResearchJasmine S. Smith - University of PennsylvaniaMona Hdeib - University of PennsylvaniaChristian Sell - Department of Pathology and Laboratory Medicine, 245 N. 15th Street, Mailstop 435, Philadelphia, PA 19102, United StatesVincent J. Cristofalo - Lankenau Institute for Medical ResearchThomas D. Stamato - Lankenau Institute for Medical Research
- Publication Details
- Mechanisms of ageing and development, v 130(11), pp 784-792
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000273864900010
- Scopus ID
- 2-s2.0-72149095996
- Other Identifier
- 991019168610004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology