Journal article
Simplified light transport model for irradiation dose calculation of photodynamic therapy
International journal of biomedical engineering and technology, v 9(1), pp 25-44
01 Jan 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A proper combination of photosensitising agent, oxygen, and a specific wavelength of light is necessary for the cytotoxic destruction of cancerous cells by Photodynamic Therapy (PDT). For a light source, semiconductor lasers are suggested for the light delivery system, however packaging of semiconductor lasers for optimal optical power output is challenging. In this paper an optimal design of a semiconductor laser package with De-Ionised (DI) water-cooling system is described and analysed. A microwave antenna is designed to provide local heating of the esophagus, leading to an increase in local oxygenation of the tumor to generate singlet oxygen for cellular death.
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Details
- Title
- Simplified light transport model for irradiation dose calculation of photodynamic therapy
- Creators
- Gemunu Happawana - California State University, FresnoAmaranath Premasiri - Akon Inc, San Jose, CA 95131 USAArye Rosen - Drexel University
- Publication Details
- International journal of biomedical engineering and technology, v 9(1), pp 25-44
- Publisher
- Inderscience Enterprises Ltd
- Number of pages
- 20
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000214219700002
- Scopus ID
- 2-s2.0-84874152107
- Other Identifier
- 991022065614904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical