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Simultaneous Presentation of Wilms Tumor and Immature Ovarian Teratoma in Beckwith-Wiedemann Syndrome
Journal article   Peer reviewed

Simultaneous Presentation of Wilms Tumor and Immature Ovarian Teratoma in Beckwith-Wiedemann Syndrome

Jason C White, Jinglan Liu and Akash Nahar
Journal of pediatric hematology/oncology, v 40(1), pp e61-e63
Jan 2018
PMID: 28692553

Abstract

Antineoplastic Combined Chemotherapy Protocols - therapeutic use Beckwith-Wiedemann Syndrome - diagnosis Beckwith-Wiedemann Syndrome - genetics Biomarkers, Tumor - analysis Child, Preschool Chromosome Aberrations Chromosomes, Human, Pair 11 Cytogenetics Diagnosis, Differential Female Humans Insulin-Like Growth Factor II - genetics Ovarian Neoplasms - complications Ovarian Neoplasms - diagnosis Remission Induction Teratoma - complications Teratoma - diagnosis Wilms Tumor - complications Wilms Tumor - diagnosis
The Beckwith-Wiedemann syndrome is a cancer predisposition syndrome characterized by a predilection to embryonal tumor growth, especially Wilms tumor, adrenocortical carcinomas, and hepatoblastomas. Genetic analysis of patients has revealed a link to the imprinted domain of the 11p15.5 chromosome and methylation status of the H19 locus and Igf-2. These genes have also been studied in other cancers, including ovarian teratomas. Our case is a patient with a simultaneous presentation of a Wilms tumor and immature ovarian teratoma and subsequently diagnosed with Beckwith-Wiedemann syndrome, which has not been previously described.

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Web of Science research areas
Hematology
Oncology
Pediatrics
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