Journal article
Simultaneous measurements of brain tissue pO 2 and cerebral blood flow during functional stimulation
International Congress series, v 1235, pp 155-163
2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Simultaneous partial pressure of tissue oxygen (
pO
2) and laser Doppler (LD) flowmetry measurements of cerebral blood flow (CBF) were obtained from the rat somatosensory cortex during periodic electrical forepaw stimulation of either 1-min or 4-s duration. For both stimulus durations, a transient significant decrease or “initial dip” in tissue
pO
2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue
pO
2. A sustained poststimulus undershoot in tissue
pO
2 was observed only for the 1-min stimulus. The magnitude of this poststimulus tissue
pO
2 decrease was significantly greater than the “initial dip” observed after stimulus onset, suggesting that relative tissue hypoxia alone does not mediate blood flow changes observed with functional stimulation. Our results suggest a complex dynamic relationship between oxygen utilization and blood flow exists during functional stimulation.
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Details
- Title
- Simultaneous measurements of brain tissue pO 2 and cerebral blood flow during functional stimulation
- Creators
- Beau M Ances - University of PennsylvaniaDonald G Buerk - University of PennsylvaniaJoel H Greenberg - University of PennsylvaniaJohn A Detre - University of Pennsylvania
- Publication Details
- International Congress series, v 1235, pp 155-163
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000178455900016
- Scopus ID
- 2-s2.0-85023059347
- Other Identifier
- 991019231646304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Physiology