Journal article
Single and joint impact of type 2 diabetes and of congestive heart failure on albuminuria
JOURNAL OF DIABETES AND ITS COMPLICATIONS, v 35(12), 108046
Dec 2021
PMID: 34598838
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims: Albuminuria is a characteristic feature of diabetic nephropathy, and urine albumin excretion is also increased in patients with congestive heart failure (CHF). However, no data are available on the single and joint associations of type 2 diabetes mellitus (T2DM) and CHF with albuminuria. This issue was addressed in the present study. Methods: We investigated 4 groups of patients: 180 patients with CHF, of whom 83 had T2DM (CHF+/T2DM+) and 97 did not have diabetes (CHF+/T2DM-) and 223 controls without CHF, of whom 39 had T2DM (CHF-/T2DM+) and 184 did not have diabetes (CHF-/T2DM-). Results: The albumin-creatinine ratio (ACR) was 9.2 [5.7-16.9] mg/g in CHF-/T2DM-patients. Compared to this group it was higher in CHF-/T2DM+ patients (16.1 [7.7-27.8] mg/g; p = 0.004), in CHF+/T2DM-patients (22.0 [9.0-76.8] mg/g; p < 0.001) and in CHF+/T2DM+ patients (66.2 [16.0-177.0] mg/g; p < 0.001), in whom in turn it was higher than in CHF-/T2DM+ (p < 0.001) or in CHF+/T2DM-(p = 0.001) patients. The ACR did not differ significantly between CHF-/T2DM+ and CHF+/T2DM-patients (p = 0.188). In multivariate analysis of covariance, CHF and T2DM proved to be independent predictors of ACR after multivariate adjustment (F = 5.68; p = 0.018 and F = 4.79; p = 0.029, respectively). Conclusions: We conclude that T2DM and CHF are mutually independent determinants of albuminuria.
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Details
- Title
- Single and joint impact of type 2 diabetes and of congestive heart failure on albuminuria
- Publication Details
- JOURNAL OF DIABETES AND ITS COMPLICATIONS, v 35(12), 108046
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Grant note
- This work was supported by the Jubilaumsfonds of the Austrian National Bank (Vienna, Austria), Dr. Karl Josef Hier and the Peter Goop Stiftung (Vaduz, Liechtenstein), the Fachhochschule Dornbirn (Dornbirn, Austria), and the Institute for Clinical Chemistry at the Academic Teaching Hospital Feldkirch (Feldkirch, Austria). We would like to thank the above mentioned for providing us with generous research grants.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000720776900018
- Scopus ID
- 2-s2.0-85115953883
- Other Identifier
- 991021860669704721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism