Journal article
Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia
NEUROPSYCHOLOGIA, v 170, 108210
06 Jun 2022
PMID: 35283160
Abstract
Influential theories of skilled action posit that distinct cognitive mechanisms and neuroanatomic substrates support meaningless gesture imitation and tool use pantomiming, and poor performance on these tasks are hallmarks of limb apraxia. Yet prior research has primarily investigated brain-behavior relations at the group level; thus, it is unclear whether we can identify individuals with isolated impairments in meaningless gesture imitation or tool use pantomiming whose performance is associated with a distinct neuroanatomic lesion profile. The goal of this study was to test the hypothesis that individuals with disproportionately worse performance in meaningless gesture imitation would exhibit cortical damage and white matter disconnection in left fronto-parietal brain regions, whereas individuals with disproportionately worse performance in tool use pantomiming would exhibit cortical damage and white matter disconnection in left temporo-parietal brain re-gions. Fifty-eight participants who experienced a left cerebrovascular accident took part in a meaningless gesture imitation task, a tool use pantomiming task, and a T1 structural MRI. Two participants were identified who had relatively small lesions and disproportionate impairments on one task relative to the other, as well as below-control-level performance on one task and not the other. Using these criteria, one participant was dispropor-tionately impaired at meaningless gesture imitation, and the other participant was disproportionately impaired at pantomiming tool use. Graph theoretic analysis of each participant's structural disconnectome demonstrated that disproportionately worse meaningless gesture imitation performance was associated with disconnection among the left inferior parietal lobule, the left superior parietal lobule, and the left middle and superior frontal gyri, whereas disproportionately worse tool use pantomiming performance was associated with disconnection between left temporal and parietal regions. Our results demonstrate that relatively focal lesions to specific portions of the Tool Use Network can be associated with distinct limb apraxia subtypes.
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Details
- Title
- Single-case disconnectome lesion-symptom mapping: Identifying two subtypes of limb apraxia
- Publication Details
- NEUROPSYCHOLOGIA, v 170, 108210
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD; OXFORD
- Grant note
- We thank Cortney Howard and Veronica Kreter for coding participants' gestures, and Austin Wild, Olu Faseyitan, Branch Coslett, and Clint Greene for help with lesion segmentation. Preparation of this manuscript was supported by a Moss Rehabilitation Research Institute/University of Pennsylvania postdoctoral training fellowship (NIH 5T32HD071844-05), and by NIH grant R01 NS099061 to L.J.B.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000794338400002
- Scopus ID
- 2-s2.0-85128264610
- Other Identifier
- 991021861304804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Psychology, Experimental