Journal article
Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure ARIC Study
Circulation (New York, N.Y.), v 137(20), pp 2142-2151
15 May 2018
PMID: 29386202
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Higher physical activity (PA) is associated with lower heart failure (HF) risk; however, the effect of changes in PA on HF risk is unknown.
METHODS: We evaluated 11 351 ARIC study (Atherosclerosis Risk in Communities) participants (mean age 60 years) who attended visit 3 (1993-1995) and did not have a history of cardiovascular disease. Exercise PA was assessed using a modified Baecke questionnaire and categorized according to American Heart Association guidelines as recommended, intermediate, or poor. We used Cox regression models to characterize the association of 6-year changes in PA between the first (1987-1989) and third ARIC visits and HF risk.
RESULTS: During a median of 19 years of follow-up, 1750 HF events occurred. Compared with those with poor activity at both visits, the lowest HF risk was seen for those with persistently recommended activity (hazard ratio, 0.69; 95% confidence interval, 0.60-0.80). However, those whose PA increased from poor to recommended also had reduced HF risk (hazard ratio, 0.77; 95% confidence interval 0.63-0.93). Among participants with poor baseline activity, each 1 SD higher PA at 6 years (512.5 METS*minutes/week, corresponding to approximate to 30 minutes of brisk walking 4 times per week) was associated with significantly lower future HF risk (hazard ratio, 0.89, 95% confidence interval, 0.82-0.96).
CONCLUSIONS: Although maintaining recommended activity levels is associated with the lowest HF risk, initiating and increasing PA, even in late middle age, are also linked to lower HF risk. Augmenting PA may be an important component of strategies to prevent HF.
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Details
- Title
- Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure ARIC Study
- Creators
- Roberta Florido - Johns Hopkins UniversityLucia Kwak - Bloomberg (United States)Mariana Lazo - Johns Hopkins MedicineVijay Nambi - Michael E. DeBakey VA Medical CenterHaitham M. Ahmed - Cleveland ClinicSheila M. Hegde - Brigham and Women's HospitalGary Gerstenblith - Church of EnglandRoger S. Blumenthal - Church of EnglandChristie M. Ballantyne - Baylor College of MedicineElizabeth Selvin - Bloomberg (United States)Aaron R. Folsom - University of MinnesotaJosef Coresh - Bloomberg (United States)Chiadi E. Ndumele - Johns Hopkins University
- Publication Details
- Circulation (New York, N.Y.), v 137(20), pp 2142-2151
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- Robert E. Meyerhoff Professorship K23HL12247 / National Institutes of Health/National Heart, Lung, and Blood Institute grant K24DK106414 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Robert Wood Johnson Amos Medical Faculty Development Award Johns Hopkins University Catalyst Award K24DK106414 / National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant K23HL122447 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000435577100010
- Scopus ID
- 2-s2.0-85049239654
- Other Identifier
- 991020550490804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease