Journal article
Sleep Neurobiology from a Clinical Perspective
Sleep (New York, N.Y.), v 34(7), pp 845-858
01 Jul 2011
PMID: 21731134
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many neurochemical systems interact to generate wakefulness and sleep. Wakefulness is promoted by neurons in the pons, midbrain, and posterior hypothalamus that produce acetylcholine, norepinephrine, dopamine, serotonin, histamine, and orexin/hypocretin. Most of these ascending arousal systems diffusely activate the cortex and other forebrain targets. NREM sleep is mainly driven by neurons in the preoptic area that inhibit the ascending arousal systems, while REM sleep is regulated primarily by neurons in the pons, with additional influence arising in the hypothalamus. Mutual inhibition between these wake- and sleep-regulating regions likely helps generate full wakefulness and sleep with rapid transitions between states. This up-to-date review of these systems should allow clinicians and researchers to better understand the effects of drugs, lesions, and neurologic disease on sleep and wakefulness.
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Details
- Title
- Sleep Neurobiology from a Clinical Perspective
- Creators
- Rodrigo A España - Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NCThomas E Scammell - Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA
- Publication Details
- Sleep (New York, N.Y.), v 34(7), pp 845-858
- Publisher
- Associated Professional Sleep Societies, LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000292926500012
- Scopus ID
- 2-s2.0-79959965737
- Other Identifier
- 991014877864704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences