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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Sleep deprivation attenuates inflammatory responses and ischemic cell death
Experimental neurology, v 218(1), pp 129-136
2009
PMID: 19409382
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although the biological function of sleep remains uncertain, the consequences of sleep deprivation are well-described and are reported to be detrimental to cognitive function and affective well-being. Sleep deprivation also is strongly associated with elevated risk factors for cardiovascular disease. We used a mouse model of cardiac arrest/cardiopulmonary resuscitation to test the hypothesis that acute sleep deprivation would exacerbate neuroinflammation and neurodegeneration after global ischemia. The resulting data led to a rejection of our hypothesis that sleep deprivation is necessarily detrimental. Indeed, acute sleep deprivation (ASD) was associated with a reduction in ischemia-induced interleukin 1β (IL-1β) gene expression and attenuation of neuronal damage in the hippocampus. Further, sleep deprivation increased gene expression of two anti-inflammatory cytokines, IL-6 and IL-10 that are associated with improved ischemic outcome. To determine whether the anti-inflammatory properties of ASD were specific to ischemia, mice were treated systemically with lipopolysaccharide (LPS), a potent inflammogen. Acute sleep deprivation attenuated the central and peripheral increase in tumor necrosis factor-α (TNFα) and increased IL-10 expression. Together, the ischemia and LPS data suggest that, ASD produces an anti-inflammatory bias that could be exploited to improve medical procedures that are compromised by inflammation.
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Details
- Title
- Sleep deprivation attenuates inflammatory responses and ischemic cell death
- Creators
- Zachary M Weil - The Ohio State UniversityGreg J Norman - The Ohio State UniversityKate Karelina - The Ohio State UniversityJohn S Morris - The Ohio State UniversityJacqueline M Barker - The Ohio State UniversityAlan J SU - The Ohio State UniversityJames C Walton - The Ohio State UniversitySteven Bohinc - The Ohio State UniversityRandy J Nelson - The Ohio State UniversityA. Courtney Devries - The Ohio State University
- Publication Details
- Experimental neurology, v 218(1), pp 129-136
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000267152100018
- Scopus ID
- 2-s2.0-67349149022
- Other Identifier
- 991020099917704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences