Journal article
Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents
Sleep (New York, N.Y.), v 42(9)
06 Sep 2019
PMID: 31181146
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sleep deprivation and low sleep quality are widespread among adolescents, and associate with obesity risk. Plausible mediators include diet and physical activity. Another potential interrelated pathway, as yet unexplored in adolescents, could involve epigenetic modification of metabolism genes.
In a cohort of 351 Mexico City adolescents (47% male; mean [SD] age = 14 [2] years), 7-day actigraphy was used to assess average sleep duration, sleep fragmentation, and movement index. DNA isolated from blood leukocytes was bisulfite-converted, amplified, and pyrosequenced at four candidate regions. Linear mixed models evaluated sex-stratified associations between sleep characteristics (split into quartiles [Q]) and DNA methylation of each region, adjusted for potential confounders.
Mean sleep duration was 8.5 [0.8] hours for boys and 8.7 [1] hours for girls. There were sex-specific associations between sleep duration and LINE-1 (long interspersed nuclear element) methylation. Boys with longer sleep duration (Q4) had lower LINE-1 methylation than boys in the 3rd quartile reference category, while girls with both longer and shorter sleep duration had higher LINE-1 methylation compared to Q3. Longer sleep duration was associated with higher H19 methylation among girls (comparing highest to third quartile, -0.9% [-2.2, 0.5]; p, trend = 0.047). Sleep fragmentation was inversely associated with peroxisome proliferator-activated receptor alpha (PPARA) methylation among girls (comparing highest to lowest fragmentation quartile, 0.9% [0.1 to 1.8]). Girls also showed an inverse association between sleep fragmentation and hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2; Q4 to Q1, 0.6% [-1.2%, 0%]).
Sleep duration and fragmentation in adolescents show sex-specific associations with leukocyte DNA methylation patterns of metabolism genes.
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Details
- Title
- Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents
- Creators
- Erica C Jansen - University of MichiganDana C Dolinoy - Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MILouise M O'Brien - University of MichiganKaren E Peterson - University of MichiganRonald D Chervin - University of MichiganMargaret Banker - University of MichiganMartha María Téllez-Rojo - National Institute of Public HealthAlejandra Cantoral - CONACYT, National Institute of Public Health, Cuernavaca, Mexico.Adriana Mercado-Garcia - National Institute of Public HealthBrisa Sanchez - Department of Epidemiology and Biostatistics Drexel University Philadelphia PAJaclyn M Goodrich - University of Michigan
- Publication Details
- Sleep (New York, N.Y.), v 42(9)
- Publisher
- Oxford University Press
- Grant note
- T32 HL110952 / NHLBI NIH HHS P30 DK020572 / NIDDK NIH HHS P01 ES022844 / NIEHS NIH HHS P20 ES018171 / NIEHS NIH HHS P30 DK089503 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000493384500005
- Scopus ID
- 2-s2.0-85073251744
- Other Identifier
- 991020100202004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences