Journal article
Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories
Cerebral cortex (New York, N.Y. 1991), v 26(1)
01 Jan 2016
PMID: 25316340
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Abstract
Phase-amplitude coupling (PAC) has been proposed as a neural mechanism for coordinating information processing across brain regions. Here we sought to characterize PAC in the human hippocampus, and in temporal and frontal cortices, during the formation of new episodic memories. Intracranial recordings taken as 56 neurosurgical patients studied and recalled lists of words revealed significant hippocampal PAC, with slow-theta activity (2.5-5 Hz) modulating gamma band activity (34-130 Hz). Furthermore, a significant number of hippocampal electrodes exhibited greater PAC during successful than unsuccessful encoding, with the gamma activity at these sites coupled to the trough of the slow-theta oscillation. These same conditions facilitate LTP in animal models, providing a possible mechanism of action for this effect in human memory. Uniquely in the hippocampus, phase preference during item encoding exhibited a biphasic pattern. Overall, our findings help translate between the patterns identified during basic memory tasks in animals and those present during complex human memory encoding. We discuss the unique properties of human hippocampal PAC and how our findings relate to influential theories of information processing based on theta-gamma interactions.
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Details
- Title
- Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories
- Creators
- Bradley Lega - Hospital of the University of PennsylvaniaJohn Burke - University of PennsylvaniaJoshua Jacobs - Drexel UniversityMichael J. Kahana - University of Pennsylvania
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), v 26(1)
- Publisher
- Oxford Univ Press
- Number of pages
- 11
- Grant note
- T32MH017168 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) MH055687 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000370972500026
- Scopus ID
- 2-s2.0-84959912193
- Other Identifier
- 991019169669004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences