Journal article
Slow axonal transport and the genesis of neuronal morphology
Journal of neurobiology, v 58(1), pp 3-17
Jan 2004
PMID: 14598366
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The classic view of slow axonal transport maintains that microtubules, neurofilaments, and actin filaments move down the axon relatively coherently at rates significantly slower than those characteristic of known motor proteins. Recent studies indicate that the movement of these cytoskeletal polymers is actually rapid, asynchronous, intermittent, and most probably fueled by familiar motors such as kinesins, myosins, and cytoplasmic dynein. This new view, which is supported by both live-cell imaging and mechanistic analyses, suggests that slow axonal transport is both rapid and plastic, and hence could underlie transformations in neuronal morphology.
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Details
- Title
- Slow axonal transport and the genesis of neuronal morphology
- Creators
- Peter W Baas - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA. Peter.W.Bass@drexel.eduDaniel W Buster
- Publication Details
- Journal of neurobiology, v 58(1), pp 3-17
- Publisher
- Wiley; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000187278800002
- Scopus ID
- 2-s2.0-0346120162
- Other Identifier
- 991014877915604721
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- Web of Science research areas
- Neurosciences