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Small-for-gestational-age births in pregnant women with HIV, due to severity of HIV disease, not antiretroviral therapy
Journal article   Open access   Peer reviewed

Small-for-gestational-age births in pregnant women with HIV, due to severity of HIV disease, not antiretroviral therapy

Erika Aaron, Alexa Bonacquisti, Leny Mathew, Gregg Alleyne, Laura P Bamford and Jennifer F Culhane
Infectious diseases in obstetrics and gynecology, v 2012, 135030
2012
DOI: https://doi.org/10.1155/2012/135030
PMID: 22778533
url
https://doi.org/10.1155/2012/135030View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Adult Anti-Retroviral Agents - therapeutic use CD4 Lymphocyte Count Female HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - immunology Humans Infant, Newborn Infant, Small for Gestational Age Pregnancy Pregnancy Complications, Infectious - epidemiology Prospective Studies Regression Analysis Risk Factors Severity of Illness Index United States - epidemiology Young Adult
To determine rate and factors associated with small-for-gestational-age (SGA) births to women with HIV. Prospective data were collected from 183 pregnant women with HIV in an urban HIV prenatal clinic, 2000-2011. An SGA birth was defined as less than the 10th or 3rd percentile of birth weight distribution based upon cut points developed using national vital record data. Bivariate analysis utilized chi-squared and t-tests, and multiple logistic regression analyses were used. The prevalence of SGA was 31.2% at the 10th and 12.6% at the 3rd percentile. SGA at the 10th (OR 2.77; 95% CI, 1.28-5.97) and 3rd (OR 3.64; 95% CI, 1.12-11.76) percentiles was associated with cigarette smoking. Women with CD4 count>200 cells/mm3 at the first prenatal visit were less likely to have an SGA birth at the 3rd percentile (OR 0.29; 95% CI, 0.10-0.86). Women taking NNRTI were less likely to have an SGA infant at the 10th (OR 0.28; 95% CI, 0.10-0.75) and 3rd (OR 0.16; 95% CI, 0.03-0.91) percentiles compared to those women on PIs. In this cohort with high rates of SGA, severity of HIV disease, not ART, was associated with SGA births after adjusting for sociodemographic, medication, and disease severity.

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